Evaluation of Oxygen Uptake Kinetic Asymmetries in Patients with Multiple Sclerosis: A Pilot Study

Rebecca D. Larson, Monica Barton, John W Farrell III, Gregory S. Cantrell, David J. Lantis, Christopher D. Black, Carl J. Ade

Abstract


Background of Study: Observations of limb to limb differences (bilateral asymmetry) in leg strength, power, peak oxygen uptake (VO2) and bone mineral density has been reported in individuals with Multiple Sclerosis (MS). Objetives: The purpose of this study was to quantify the magnitude of bilateral asymmetries in oxygen uptake (VO2) kinetics response to single leg cycling (SLC) in relapsing-remitting multiple sclerosis (MS) patients. Methods: Five MS
patients (2 men, 3 women; age 43±7 yrs) performed constant work rate SLC trials to determine VO2 kinetics in each leg. Asymmetry scores were used to quantify the magnitude of the bilateral asymmetries. Results: Significant asymmetries were seen in VO2 peak and parameters of VO2 kinetics. VO2peak asymmetry score was significantly different than 0% (p=0.015). Similarly,
significant asymmetry for VO2 kinetic response to exercise as mean response time was observed (p=0.03). In addition the VO2 response to exercise resulted in a significant asymmetry in VO2 deficit between legs (p=0.03). No correlation between EDSS scores and any asymmetry scores existed. Conclusions: These findings provide insight into the potential differences in metabolic perturbation and limb specific symptomatic fatigue within the MS population.


Keywords


Multiple Sclerosis, Exercise, Oxygen, Asymmetry

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References


Abbiss, C. R., & Laursen, P. B. (2005). Models to explain fatigue during prolonged endurance cycling. Sports Medicine, 35(10), 865-898.

Compston, A., & Coles, A. (2008). Multiple Sclerosis. Multiple Sclerosis, 372(9648), 1502–17.

Chung, L.H., Remelius, J.G., Van Emmerik, R.E. & Kent-Braun, J.A. (2008). Leg power asymmetry and postural control in women with multiple sclerosis. Medicine and science in sports and exercise, 40(10), 1717-24.

Hansen, D., Wens, I., Kosten, L., Verboven, K. & Eijnde, B.O. (2013). Slowed exercise-onset Vo2 kinetics during submaximal endurance exercise in subjects with multiple sclerosis. Neurorehabilitation and neural repair, 27(1), 87-95.

Larson, R.D., McCully, K.K., Larson, D.J., Pryor, W.M. & White LJ. (2013). Bilateral differences in lower-limb performance in individuals with multiple sclerosis. Journal of rehabilitation research and development, 50(2), 215-22.

Mao , P., & Reddy, P.H. (2010). Is multiple sclerosis a mitochondrial disease? Biochimica et biophysica acta, 1802(1), 66-79.

Ponichtera-Mulcare, J. A. (1993). Exercise and multiple sclerosis. Medicine & Science in Sports & Exercise, 25(4), 451–465.

Poole, D.C., Barstow, T.J., McDonough, P., & Jones, A.M. (2008). Control of oxygen uptake during exercise. Medicine and science in sports and exercise, 40(3), 462-74.

Poole, D. C., & Jones, A. M. (2012). Oxygen uptake kinetics. Comprehensive Physiology, 2(2), 933–996.

Poole, D.C., Schaffartzik, W., Knight, D.R., Derion, T., Kennedy, B., Guy, H.J., Prediletto, R., & Wagner, P.D. (1991). Contribution of exercising legs to the slow component of oxygen uptake kinetics in humans. Journal of applied physiology, 71(4), 1245-60.

Romani, A., Bergamaschi ,R., Candeloro, E., Alfonsi, E., Callieco, R., & Cosi, V. (2004). Fatigue in multiple sclerosis: multidimensional assessment and response to symptomatic treatment. Multiple sclerosis, 10(4), 462-8.

Sandroff, B. M., Sosnoff, J. J., & Motl, R. W. (2013). Physical fitness, walking performance, and gait in multiples

sclerosis. Journal of the Neurological sciences, 328(1-2), 70–76.

Whipp, B. J., Ward, S. A., Lamarra, N., Davis, J. A., & Wasserman, K. (1982). Parameters of ventilatory and gas

exchange dynamics during exercise. Journal of Applied Physiology, 52(6), 1506–1513.




DOI: https://doi.org/10.7575/aiac.ijkss.v.6n.4p.21

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